What do we provide?

This website contains sequence-based predictions to help understand the behavior of proteins that compose the human proteome. Not all of these proteins (or regions thereof) have a well-defined three-dimensional structure (as available from PDB), and might exhibit ambiguous, dynamic behavior. With our predictions, we provide clues on how such regions in these proteins might behave.

How do I proceed?

Click here on 'Entries' (or do so in the top bar) to see the list of proteins for which we provide predictions. This list is a compilation of entries provided by Uniprot organized by:

  • The Uniprot ID. Click on this name to see the sequence-based predictions for this protein
  • The Chromosome of the gene
  • The Gene name
  • The Protein Name
  • The amino acid sequence length of the protein
  • The header and trailer amino acids of the protein
  • The available files to download

The pages with the per-protein sequence-based predictions provide:

  • Overview: A plot of all incorporated sequence-based predictions.
  • Interpretation: Biophysical Interpretation of Disorder using a Random Forest classifier Based on the article published on Frontiers in Molecular Biosciences in 2022.
  • Values: A tabular representation of all the sequence-based predictions.
  • Statistics: A tabular representation of the statistics of all the sequence-based predictions including mean, median, minimum, maximum, and others.
  • Sequence: The sequence in FASTA format colourized by the different prediction values.
  • Plots: The plots per sequence-based predictor.
  • PSP (Phase Separating Protein): A plot of Phase Separation using the PSPer predictor.
  • Visualization 1D-3D: A 3D visualization tool showing the AlphaFold model colourized by the different prediction values.
  • Help: A briefly summary of the available predictions.