Bio2Byte SARS-CoV-2

(N)ucleocapsid

Sequence Length: 419 AA

Function

Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection.

Biophysical predictions overview

Biophysical features overview

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The above plot shows the following predictions for the YP_009724397 SARS-CoV-2 protein:

DynaMine backbone dynamics	Values above 0.8 indicate rigid conformations, values above 1.0 membrane spanning regions, values below 0.69 flexible regions. Values between 0.80-0.69 are 'context' dependent and capable of being either rigid or flexible.
DynaMine sidechain dynamics	Higher values mean more likely rigid. These values are highly dependent on the amino acid type (i.e. a Trp will be rigid, an Asp flexible).
DynaMine conformational propensities (sheet, helix, coil)	Higher values indicate higher propensities.
EFoldMine earlyFolding propensity	Values above 0.169 indicate residues that are likely to start the protein folding process, based on only local interactions with other amino acids.
Disomine disorder	Values above 0.5 indicate that this is likely a disordered residue.
Agmata aggregation propensity	These values are divided by a factor of 20 from the original. Peaks indicate residues likely to be involved in beta-sheet aggregation.
SeRenDIP protein-protein interactions (PPI)	Values above 0.5 indicate that this residue likely participates in protein-protein interactions.
SeRenDIP epitopes (epitope)	Values above 0.5 indicate that this residue is predicted to be recognised as an epitope.

These predictions reflect 'emerging' properties, so what the sequence is capable of, not necessarily what it will adopt in a final fold.

MSA-based value range for prediction

The selected prediction below this message is visualized in the context of the MSA. Therefore, there may be gaps where the selected protein lacks values. You can still visualize all the statistical fields for these gaps in the alignment.

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