Description of the methodology used
About this website
On this website, you can explore which amino acid residues in proteins that are predicted to be early folding, this in relation to the sequence fragment it occurs in, and the final secondary structure this fragment adopts in the protein (when folded). In addition, we provide information about why the machine learning method used for the prediction has classified this residue as 'early folding'.
Sequence based predictions
The DynaMine backbone and sidechain dynamics and conformational propensities are described in:
- From protein sequence to dynamics and disorder with DynaMine
Nature Communications 4, 3741 (2013).
- The DynaMine webserver: Predicting protein dynamics from sequence
Nucleic Acids Research 42, W264-W270 (2014).
The DynaMine-based predictions serve as input features for the pEFoldMine early folding predictions, which are described in:
- Exploring the Sequence-based Prediction of Folding Initiation Sites in Proteins
Scientific Reports 7, 8826 (2017).