Traditionally, proteins are described in a single static state (a picture). It is now increasingly recognised that many proteins can adopt multiple states and move between these conformational states dynamically (a movie). Even more, not every protein has a well-defined three-dimensional structure, many are partly or fully disordered. These predictions describe backbone and side-chain dynamics, disorder, early folding events, beta-sheet aggregation and phase separation.
In this atlas
Entries here
Genes
Chromosomes
Reviewed in UniProt
Last updated 2 days, 8 hours ago.
About this proteome
Extracted from UniProtKB
Drosophila melanogaster is a fruit fly and the most studied species from the family Drosophilidae. It has been used as a model organism for genetic and developmental studies since the first experiments on sex-linkage and genetic recombination carried out by Thomas Hunt Morgan in the 1900s. Its importance for human health was recognized by the award of the Nobel Prize in medicine/physiology to Ed Lewis, Christiane Nusslein-Volhard and Eric Wieschaus in 1995 for their research on the genetic control of embryonic development. Moreover, recent genetic analyses have shown that around 75% of human disease genes have homologs in Drosophila melanogaster The Drosophila melanogaster complete genome sequence was published in 2000. It contains 180 Mb (one third of which is centric heterochromatin) and approximately 14,000 protein-coding genes.
What is included
This atlas covers the reviewed entries of this proteome — the manually curated Swiss-Prot section of UniProtKB. That is 17.6% of it. The other 18,080 entries are unreviewed (TrEMBL) and are not included, which is why the count above is smaller than the proteome. You can run the same predictions on any of them yourself in the online predictors.
- UniProt proteome
- UP000000803
- Taxonomy
- 7227 · DROME
- Proteome type
- Reference proteome
- Strain
- Berkeley
- Superkingdom
- eukaryota
- Genome assembly
- GCA_000001215.4 · ENA/EMBL
- Completeness (BUSCO)
- 100% · 3285/3285
Source: UniProt proteome UP000000803, last modified 5 Dec 2025. Retrieved 19 Aug 2026 (2 days, 8 hours ago) and cached for a week.
Most viewed fruit fly proteins
What visitors are reading in this proteome — 3 entry views in total.
- 1 P23572 · Cdk1 Chromosome 2L 3 views
What do we provide?
Sequence-based predictions that help explain the behaviour of the proteins in the fruit fly proteome. Not all of these proteins, or regions of them, have a well-defined three-dimensional structure as available from the PDB; many are dynamic or ambiguous. These predictions give clues as to how such regions behave.
- DynaMine
- backbone and side-chain dynamics
- DisoMine
- disorder
- EFoldMine
- early folding
- AgMata
- beta-sheet aggregation
- PSPer
- phase separation
How do I proceed?
Open the entry list and click a UniProt accession. Each entry page carries:
- Overview — every prediction on one plot.
- Interpretation — disorder classified as order, transition or disorder.
- Values and Statistics — the numbers behind the plots.
- Sequence — residues coloured by prediction.
- PSP — phase-separation propensity.
- Visualization 1D-3D — a 3D model coloured by prediction.
- Downloads — sequence, predictions and structures.
Prefer code? Everything is available through the REST API.