Traditionally, proteins are described in a single static state (a picture). It is now increasingly recognised that many proteins can adopt multiple states and move between these conformational states dynamically (a movie). Even more, not every protein has a well-defined three-dimensional structure, many are partly or fully disordered. These predictions describe backbone and side-chain dynamics, disorder, early folding events, beta-sheet aggregation and phase separation.
In this atlas
Entries here
Genes
Chromosomes
Reviewed in UniProt
Last updated 43 seconds ago.
About this proteome
Extracted from UniProtKB
Homo sapiens (Homo sapiens sapiens) or modern humans are the only living species of the evolutionary branch of great apes known as hominids. Divergence of early humans from chimpanzees and gorillas is estimated to have occurred between 4 and 8 million years ago. The genus Homo (Homo habilis) appeared in Africa around 2.3 million years ago and shows the first signs of stone tool usage. The exact lineage of Homo species ie: H. habilis/H. ergaster to H. erectus to H. rhodesiensis/H.heidelbergensis to H. sapiens is still hotly disputed. However, continuing evolution and in particular larger brain size and complexity culminates in Homo sapiens. The first anatomically modern humans appear in the fossil record around 200,000 years ago. Modern humans migrated across the globe essentially as hunter-gatherers until around 12,000 years ago when the practice of agriculture and animal domestication enabled large populations to grow leading to the development of civilizations.
What is included
This atlas covers the reviewed entries of this proteome — the manually curated Swiss-Prot section of UniProtKB. That is 13.8% of it. The other 127,104 entries are unreviewed (TrEMBL) and are not included, which is why the count above is smaller than the proteome. You can run the same predictions on any of them yourself in the online predictors.
- UniProt proteome
- UP000005640
- Taxonomy
- 9606 · HUMAN
- Proteome type
- Reference proteome
- Superkingdom
- eukaryota
- Genome assembly
- GCA_000001405.29 · Ensembl
- Completeness (BUSCO)
- 99% · 13716/13780
- Imported from release
- 2026_03
Source: UniProt proteome UP000005640, last modified 22 Apr 2026. Retrieved 10 Sep 2026 (1 day ago) and cached for a week.
Most viewed human proteins
What visitors are reading in this proteome — 26,272 entry views in total.
- 1 P04637 · TP53 Chromosome 17 36 views
- 2 P52292 · KPNA2 Chromosome 17 34 views
- 3 Q9Y577 · TRIM17 Chromosome 1 18 views
- 4 Q3ZM63 · ETDA Chromosome X 14 views
- 5 Q5TAH2 · SLC9C2 Chromosome 1 14 views
- 6 Q8NI35 · PATJ Chromosome 1 14 views
- 7 Q7L8J4 · SH3BP5L Chromosome 1 13 views
- 8 O15228 · GNPAT Chromosome 1 12 views
- 9 P35573 · AGL Chromosome 1 12 views
- 10 Q8NGD1 · OR4N2 Chromosome 14 12 views
What do we provide?
Sequence-based predictions that help explain the behaviour of the proteins in the human proteome. Not all of these proteins, or regions of them, have a well-defined three-dimensional structure as available from the PDB; many are dynamic or ambiguous. These predictions give clues as to how such regions behave.
- DynaMine
- backbone and side-chain dynamics
- DisoMine
- disorder
- EFoldMine
- early folding
- AgMata
- beta-sheet aggregation
- PSPer
- phase separation
How do I proceed?
Open the entry list and click a UniProt accession. Each entry page carries:
- Overview — every prediction on one plot.
- Interpretation — disorder classified as order, transition or disorder.
- Values and Statistics — the numbers behind the plots.
- Sequence — residues coloured by prediction.
- PSP — phase-separation propensity.
- Visualization 1D-3D — a 3D model coloured by prediction.
- Downloads — sequence, predictions and structures.
Prefer code? Everything is available through the REST API.